Read on for expert advice from Dr. Parker, a Hello Ralphie online veterinarian. Is Aspirin Safe for Dogs? Giving a Dog Aspirin Can Lead to Other Serious Issues Please note, it is never safe to administer aspirin to cats- it can be lethal. It is important to always remember our pets are not fuzzy humans and that they have different ways they metabolize medication. It is always best to contact a vet if you think your dog or cat is in pain, instead of taking to your medicine cabinet.